Hebei Lingding Biotechnology Co., Ltd.

Heparin sodium is an anticoagulant, a kind of mucopolysaccharide substance, which is the sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. In human body, it is secreted by mast cells and naturally exists in blood. Heparin sodium has the function of preventing platelet aggregation and destruction, inhibiting the transformation of fibrinogen into fibrin monomer, inhibiting the formation of thrombin and fighting the formed thrombin, preventing the transformation of prothrombin into thrombin and antithrombin, etc. Heparin can delay or prevent blood clotting both in vivo and in vitro. The mechanism of its action is very complex and it affects many links in the coagulation process. Its functions are as follows: (1) inhibit the formation and action of thrombin, so as to prevent prothrombin from becoming thrombin; In high concentration fashion can inhibit thrombin and other coagulation factors and hinder the transformation of fibrinogen into fibrin; Can prevent platelet agglutination and destruction. In addition, the anticoagulant effect of heparin sodium is related to the sulfate group with negative charge in its molecule, and the alkaline substances with positive charge, such as protamine or toluidine blue, can neutralize its negative charge, so it can inhibit its anticoagulant use for Chemicalbook. Because heparin can activate and release lipoprotein esterase in the body and hydrolyze the triglyceride and low density lipoprotein of chylomicron, it also has the effect of lowering blood lipid. Heparin sodium can be used to treat acute thromboembolic disease, disseminated intravascular coagulation (DIC). In recent years, heparin has been found to have the effect of removing blood lipid. Intravenous injection or deep intramuscular injection (or subcutaneous injection), each time 5000 to 10000 units. The toxicity of heparin sodium is low, and the tendency of spontaneous bleeding is the main risk of heparin overdose. Oral administration does not work and must be administered by injection. Intramuscular injection or subcutaneous injection stimulation is larger, occasionally allergic reaction may occur, more than the amount can even make cardiac arrest; Occasional alopecia and diarrhea are seen. In addition, it can cause spontaneous fractures.