Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Pimobendan
CAS No.: 74150-27-9
Molecular Formula: C₁₉H₁₈N₂O₂
Molecular Weight: 306.36
EINECS No.: Not available
Related Categories: Cardiotonics; Phosphodiesterase III Inhibitors; Calcium Sensitizers; Veterinary Pharmaceuticals
Use: Management of mild, moderate, or severe congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM) in dogs
Description: Pimobendan is a benzimidazole-pyridazinone derivative with dual mechanisms: it sensitizes cardiac troponin C to calcium (enhancing contractility without increasing oxygen demand) and inhibits phosphodiesterase III (causing vasodilation). This “inodilator” effect improves stroke volume, reduces preload and afterload, and prolongs survival in dogs with CHF. It is administered orally twice daily and is often used alongside furosemide, ACE inhibitors, and spironolactone in standard heart failure protocols.